Abstract
Bioassay-guided fractionation of a culture extract of Beauveria felina EN-135, an entomopathogenic fungus isolated from a marine bryozoan, led to the isolation of a new cyclodepsipeptide, iso-isariin D (1); two new O-containing heterocyclic compounds that we have named felinones A and B (2 and 3); and four known cyclodepsipeptides (4-7). The structures were elucidated via spectroscopic analysis, and the absolute configurations of 1 and 2 were determined using single-crystal X-ray diffraction and CD, respectively. All isolated compounds were evaluated for antimicrobial activity and brine-shrimp (Artemia salina) lethality.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Anti-Bacterial Agents / chemistry
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Anti-Bacterial Agents / isolation & purification
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Anti-Bacterial Agents / pharmacology
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / isolation & purification
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Antineoplastic Agents / pharmacology
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Artemia
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Bacteria / drug effects
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Beauveria / chemistry*
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Depsipeptides / chemistry*
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Depsipeptides / isolation & purification
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Depsipeptides / pharmacology
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Drug Screening Assays, Antitumor
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Fungi / drug effects
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Heterocyclic Compounds / chemistry*
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Heterocyclic Compounds / isolation & purification
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Heterocyclic Compounds / pharmacology
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Microbial Sensitivity Tests
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Models, Molecular
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Molecular Conformation
Substances
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Anti-Bacterial Agents
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Antineoplastic Agents
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Depsipeptides
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Heterocyclic Compounds
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felinone A
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felinone B
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iso-isariin D