NSs protein of Schmallenberg virus counteracts the antiviral response of the cell by inhibiting its transcriptional machinery

J Gen Virol. 2014 Aug;95(Pt 8):1640-1646. doi: 10.1099/vir.0.065425-0. Epub 2014 May 14.

Abstract

Bunyaviruses have evolved a variety of strategies to counteract the antiviral defence systems of mammalian cells. Here we show that the NSs protein of Schmallenberg virus (SBV) induces the degradation of the RPB1 subunit of RNA polymerase II and consequently inhibits global cellular protein synthesis and the antiviral response. In addition, we show that the SBV NSs protein enhances apoptosis in vitro and possibly in vivo, suggesting that this protein could be involved in SBV pathogenesis in different ways.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Host-Pathogen Interactions*
  • Humans
  • Immune Evasion*
  • Orthobunyavirus / immunology
  • Orthobunyavirus / physiology*
  • Proteolysis
  • RNA Polymerase II / metabolism*
  • Viral Nonstructural Proteins / metabolism*

Substances

  • Viral Nonstructural Proteins
  • RNA Polymerase II