Abstract
Garlic (Allium sativam L.) is widely used in traditional herbal remedies and alternative medicine. The potential health benefits of garlic are largely attributed to its metabolic byproducts. Extensive in vivo and in vitro studies has demonstrated that the garlic derivatives possess anti-cancer effects, but the underlying mechanisms are not completely understood. In this mini-review, we aim to summarize the reported biological effects of garlic products as anti-tumor agents, and present the possible molecular mechanisms responsible for the anti-carcinogenesis effects of garlic and its derivatives.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Allyl Compounds / chemistry
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Allyl Compounds / isolation & purification
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Allyl Compounds / pharmacology*
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Animals
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Antineoplastic Agents, Phytogenic / chemistry
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Antineoplastic Agents, Phytogenic / isolation & purification
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Antineoplastic Agents, Phytogenic / pharmacology*
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Apoptosis / drug effects
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Cell Cycle / drug effects
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Cell Proliferation / drug effects
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Garlic / chemistry*
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Humans
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Neoplasms / drug therapy*
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Neoplasms / pathology
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Sulfides / chemistry
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Sulfides / isolation & purification
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Sulfides / pharmacology*
Substances
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Allyl Compounds
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Antineoplastic Agents, Phytogenic
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Sulfides
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allyl sulfide