Abstract
Statins are widely used lipid-lowering drugs that are effective in reducing cardiovascular disease risk. Although they are generally well tolerated, they can cause muscle toxicity, which can lead to severe rhabdomyolysis. Research in this area has been hampered to some extent by the lack of standardized nomenclature and phenotypic definitions. We have used numerical and descriptive classifications and developed an algorithm to define statin-related myotoxicity phenotypes, including myalgia, myopathy, rhabdomyolysis, and necrotizing autoimmune myopathy.
Publication types
-
Consensus Development Conference
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Autoimmune Diseases / chemically induced
-
Autoimmune Diseases / classification
-
Humans
-
Hydroxymethylglutaryl-CoA Reductase Inhibitors / adverse effects*
-
Muscular Diseases / chemically induced*
-
Muscular Diseases / classification
-
Myalgia / chemically induced
-
Myalgia / classification
-
Myositis / chemically induced
-
Myositis / classification
-
Phenotype
-
Rhabdomyolysis / chemically induced
-
Rhabdomyolysis / classification
-
Risk Factors
-
Terminology as Topic
-
Time Factors
Substances
-
Hydroxymethylglutaryl-CoA Reductase Inhibitors