RNAi therapies: drugging the undruggable

Sci Transl Med. 2014 Jun 11;6(240):240ps7. doi: 10.1126/scitranslmed.3008362.

Abstract

RNA interference (RNAi) therapy is a rapidly emerging platform for personalized cancer treatment. Recent advances in small interfering RNA delivery and target selection provide unprecedented opportunities for clinical translation. Here, we discuss these advances and present strategies for making RNAi-based therapy a viable part of cancer management.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Genetic Therapy / methods*
  • Humans
  • Neoplasms / genetics
  • Neoplasms / therapy
  • RNA Interference / physiology
  • RNA, Small Interfering / genetics
  • RNA, Small Interfering / physiology

Substances

  • RNA, Small Interfering