Asterosaponins from the Far Eastern starfish Leptasterias ochotensis and their anticancer activity

Timofey V Malyarenko; Alla A Kicha; Natalia V Ivanchina; Anatoly I Kalinovsky; Roman S Popov; Olesya S Vishchuk; Valentin A Stonik

doi:10.1016/j.steroids.2014.05.027

Asterosaponins from the Far Eastern starfish Leptasterias ochotensis and their anticancer activity

Steroids. 2014 Sep:87:119-27. doi: 10.1016/j.steroids.2014.05.027. Epub 2014 Jun 11.

Authors

Timofey V Malyarenko¹, Alla A Kicha¹, Natalia V Ivanchina¹, Anatoly I Kalinovsky¹, Roman S Popov¹, Olesya S Vishchuk¹, Valentin A Stonik²

Affiliations

¹ G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far East Branch of the Russian Academy of Sciences, Pr. 100-let Vladivostoku 159, 690022 Vladivostok, Russia.
² G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far East Branch of the Russian Academy of Sciences, Pr. 100-let Vladivostoku 159, 690022 Vladivostok, Russia. Electronic address: stonik@piboc.dvo.ru.

PMID: 24929047
DOI: 10.1016/j.steroids.2014.05.027

Abstract

Six new asterosaponins, leptasteriosides A-F (3-8), one new and one previously known asterogenins (1, 2) were isolated from the alcoholic extract of the Far Eastern starfish Leptasterias ochotensis. The structures of 1-8 were elucidated by extensive NMR and ESI-MS techniques. Compounds 2-8 showed slight or moderate cytotoxic activities against cancer cell lines RPMI-7951 and T-47D. The asterosaponins 3-5 demonstrated a significant inhibition of RPMI-7951 and T-47D cell colony formation in soft agar clonogenic assay in nontoxic doses.

Keywords: Asterosaponins; Clonogenic assay; Cytotoxicity; Leptasterias ochotensis; Starfish.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antineoplastic Agents / isolation & purification
Antineoplastic Agents / pharmacology*
Cell Line, Tumor
Dose-Response Relationship, Drug
Humans
Saponins / isolation & purification
Saponins / pharmacology*
Starfish / chemistry*

Substances

Antineoplastic Agents
Saponins