(89)Zr-labeled compounds for PET imaging guided personalized therapy

Danielle J Vugts; Guus A M S van Dongen

doi:10.1016/j.ddtec.2011.12.004

(89)Zr-labeled compounds for PET imaging guided personalized therapy

Drug Discov Today Technol. 2011 Summer;8(2-4):e53-61. doi: 10.1016/j.ddtec.2011.12.004.

Authors

Danielle J Vugts¹, Guus A M S van Dongen²

Affiliations

¹ Department of Nuclear Medicine and PET Research, VU University Medical Center, Amsterdam, The Netherlands. Electronic address:d.vugts@vumc.nl.
² Department of Nuclear Medicine and PET Research, VU University Medical Center, Amsterdam, The Netherlands.

PMID: 24990263
DOI: 10.1016/j.ddtec.2011.12.004

Abstract

(89)Zr-immuno-PET is an attractive option for the in vivo evaluation of monoclonal antibodies (mAbs). For the coupling of (89)Zr to monoclonal antibodies several conjugation strategies are available all using desferrioxamine as chelate. Here we discuss the production of (89)Zr, the available methods for coupling of (89)Zr via desferrioxamine to mAbs, and the evaluation of (89)Zr-mAb conjugates in preclinical and clinical studies.: