Driving glioblastoma growth by alternative polyadenylation

Ting Han; John K Kim

doi:10.1038/cr.2014.88

Driving glioblastoma growth by alternative polyadenylation

Cell Res. 2014 Sep;24(9):1023-4. doi: 10.1038/cr.2014.88. Epub 2014 Jul 4.

Authors

Ting Han¹, John K Kim²

Affiliations

¹ Department of Biochemistry, UT Southwestern Medical Center, Dallas, TX 75390-9152, USA.
² Life Sciences Institute, Department of Human Genetics, University of Michigan, Ann Arbor, MI 48109-2216, USA.

Abstract

Global shortening of 3' untranslated regions (3' UTRs) through alternative polyadenylation is an emerging hallmark of cancer. A recent study identifies the cleavage factor Im 25 (CFIm25) as an important mediator of 3' UTR shortening in glioblastomas and demonstrates a causal relationship between alternative polyadenylation and cancer cell proliferation.

Publication types

Comment

MeSH terms

Animals
Carcinogenesis / genetics*
Gene Expression Regulation, Neoplastic*
Glioblastoma / physiopathology*
Humans
Male
Polyadenylation*
RNA, Messenger / metabolism*
mRNA Cleavage and Polyadenylation Factors / metabolism*

Substances

RNA, Messenger
mRNA Cleavage and Polyadenylation Factors