Stressing the limits of focal adhesion mechanosensitivity

Patrick W Oakes; Margaret L Gardel

doi:10.1016/j.ceb.2014.06.003

Stressing the limits of focal adhesion mechanosensitivity

Curr Opin Cell Biol. 2014 Oct:30:68-73. doi: 10.1016/j.ceb.2014.06.003. Epub 2014 Jul 5.

Authors

Patrick W Oakes¹, Margaret L Gardel²

Affiliations

¹ James Franck Institute, Institute for Biophysical Dynamics and Physics Department, University of Chicago, Chicago, IL, United States.
² James Franck Institute, Institute for Biophysical Dynamics and Physics Department, University of Chicago, Chicago, IL, United States. Electronic address: gardel@uchicago.edu.

Abstract

Focal adhesion assembly and maturation often occurs concomitantly with changes in force generated within the cytoskeleton or extracellular matrix. To coordinate focal adhesion dynamics with force, it has been suggested that focal adhesion dynamics are mechanosensitive. This review discusses current understanding of the regulation of focal adhesion assembly and force transmission, and the limits to which we can consider focal adhesion plaques as mechanosensitive entities.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Biomechanical Phenomena
Cell Adhesion / physiology
Cytoskeleton / metabolism
Extracellular Matrix / metabolism
Focal Adhesions* / physiology
Stress, Physiological*

Grants and funding

DP1 OD003354/OD/NIH HHS/United States