Nuclear envelope breakdown: actin' quick to tear down the wall

Binyam Mogessie; Melina Schuh

doi:10.1016/j.cub.2014.05.059

Nuclear envelope breakdown: actin' quick to tear down the wall

Curr Biol. 2014 Jul 7;24(13):R605-7. doi: 10.1016/j.cub.2014.05.059.

Authors

Binyam Mogessie¹, Melina Schuh²

Affiliations

¹ MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge Biomedical Campus, Cambridge CB2 0QH, UK.
² MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge Biomedical Campus, Cambridge CB2 0QH, UK. Electronic address: mschuh@mrc-lmb.cam.ac.uk.

PMID: 25004364
DOI: 10.1016/j.cub.2014.05.059

Abstract

Nuclear envelope breakdown in metazoan cells is thought to be facilitated by microtubules, which pull on the nuclear membranes. Unexpectedly, an F-actin meshwork helps to tear down the large nucleus of starfish oocytes and to prevent chromosome loss in meiosis.

MeSH terms

Actins / metabolism*
Animals
Meiosis / physiology*
Models, Biological*
Nuclear Envelope / metabolism*
Oocytes / cytology
Oocytes / physiology*
Starfish / physiology*

Substances

Actins

Grants and funding

MC_U105192711/MRC_/Medical Research Council/United Kingdom