The importance of 1,2-dithiolane structure in α-lipoic acid for the downregulation of cell surface β1-integrin expression of human bladder cancer cells

Masao Yamasaki; Shozen Soda; Yoichi Sakakibara; Masahito Suiko; Kazuo Nishiyama

doi:10.1080/09168451.2014.943647

The importance of 1,2-dithiolane structure in α-lipoic acid for the downregulation of cell surface β1-integrin expression of human bladder cancer cells

Biosci Biotechnol Biochem. 2014;78(11):1939-42. doi: 10.1080/09168451.2014.943647. Epub 2014 Aug 1.

Authors

Masao Yamasaki¹, Shozen Soda, Yoichi Sakakibara, Masahito Suiko, Kazuo Nishiyama

Affiliation

¹ a Faculty of Agriculture, Department of Biochemistry and Applied Biosciences , University of Miyazaki , Miyazaki , Japan.

PMID: 25081893
DOI: 10.1080/09168451.2014.943647

Abstract

Here, we show that cell surface β1-integrin expression, cell adhesion to fibronectin, migration, and invasion were all significantly inhibited by α-lipoic acid. These effects were not observed when cells were treated with dihydrolipoic acid or caprylic acid. These data reveal that the 1,2-dithiolane structure plays an important role in the action of α-lipoic acid.

Keywords: bladder cancer cells; invasion; migration; α-lipoic acid; β1-integrin.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Cell Line, Tumor
Cell Proliferation / drug effects
Down-Regulation / drug effects*
Humans
Integrin beta1 / genetics*
Thioctic Acid / analogs & derivatives*
Thioctic Acid / chemistry*
Thioctic Acid / pharmacology*
Urinary Bladder Neoplasms / metabolism*

Substances

1,2-dithiolane
Integrin beta1
Thioctic Acid