The use of poly(methacrylic acid) nanogel to control the release of amoxycillin with lower cytotoxicity

Mater Sci Eng C Mater Biol Appl. 2014 Oct:43:622-9. doi: 10.1016/j.msec.2014.07.067. Epub 2014 Aug 2.

Abstract

In order to control the release of amoxycillin (AM) with lower cytotoxicity and higher activity, ethylene glycol dimethacrylate was used as the cross-linker, and a series of poly(methacrylic acid) (PMAA) nanogels were prepared to load the AM. Then, the morphology, size, in vitro release property, long-term antibacterial performance, cytotoxicity, stability and activity of this novel AM/PMAA nanogel were investigated. The results showed that the AM/PMAA nanogel sustainably released AM with long-term antibacterial activity. Moreover, the AM/PMAA nanogel could improve the stability of AM. More importantly, this AM/PMAA nanogel showed slighter cytotoxicity than AM alone, suggesting that the AM/PMAA nanogel was a more useful dosage form than AM for infectious diseases.

Keywords: Amoxicillin; Cytotoxicity; Long-term activity; Nanogel; Poly(methacrylic acid); Sustained release.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amoxicillin / administration & dosage*
  • Amoxicillin / pharmacology
  • Anti-Bacterial Agents / administration & dosage*
  • Escherichia coli / drug effects
  • Gels*
  • Microbial Sensitivity Tests
  • Microscopy, Electron, Scanning
  • Nanostructures*
  • Polymethacrylic Acids / chemistry*
  • Staphylococcus aureus / drug effects

Substances

  • Anti-Bacterial Agents
  • Gels
  • Polymethacrylic Acids
  • polymethacrylic acid
  • Amoxicillin