Abstract
closo-Dodecaborate-encapsulating liposomes were developed as boron delivery vehicles for neutron capture therapy. The use of spermidinium as a counter cation of closo-dodecaborates was essential not only for the preparation of high boron content liposome solutions but also for efficient boron delivery to tumors.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antineoplastic Agents / administration & dosage*
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Antineoplastic Agents / chemistry
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Boron / administration & dosage
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Boron Compounds / administration & dosage*
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Boron Compounds / chemistry
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Boron Neutron Capture Therapy
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Cell Line, Tumor
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Cell Survival / drug effects
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Female
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Liposomes
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Mice, Inbred BALB C
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Neoplasms / pathology
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Neoplasms / therapy
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Tumor Burden / drug effects
Substances
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Antineoplastic Agents
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Boron Compounds
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Liposomes
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dodecaborate
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Boron