Abstract
In this study we assessed the BDNF promoter IV methylation state of a large genomic region surrounding promoter IV and evaluated BDNF transcript IV expression from prefrontal cortex and striatum of 15 schizophrenic and 15 control subjects. In prefrontal cortex, a single CpG site at -93, appeared to be undermethylated in patients׳group. BDNF mRNA levels in frontal cortex and striatum were variable among individuals but did not associate with disease.
Keywords:
BDNF; DNA methylation; Schizophrenia.
Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Adult
-
Aged, 80 and over
-
Brain-Derived Neurotrophic Factor / genetics*
-
Corpus Striatum / metabolism
-
Corpus Striatum / pathology
-
DNA Methylation / genetics*
-
Female
-
Frontal Lobe / metabolism
-
Gene Expression / genetics
-
Humans
-
Male
-
Middle Aged
-
Prefrontal Cortex / metabolism*
-
Prefrontal Cortex / pathology
-
Promoter Regions, Genetic / genetics
-
RNA, Messenger / metabolism
-
Schizophrenia / genetics*
-
Schizophrenia / pathology
-
Statistics as Topic
-
Young Adult
Substances
-
Brain-Derived Neurotrophic Factor
-
RNA, Messenger
-
BDNF protein, human