The effects of liraglutide on male fertility: a case report

Reprod Biomed Online. 2014 Nov;29(5):644-6. doi: 10.1016/j.rbmo.2014.07.009. Epub 2014 Jul 29.

Abstract

Liraglutide is an agonist of the glucagon-like peptide I receptor, and is commonly recommended as a treatment for obesity and type 2 diabetes mellitus. Adverse effects related to liraglutide include acute pancreatitis and polyarthritis. No studies, however, have reported an adverse effect of liraglutide on male reproduction. This case report shows a deleterious effect of liraglutide on male reproductive function.

Keywords: liraglutide; male infertility; male reproduction; spermatozoa.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Diabetes Mellitus, Type 2 / complications
  • Diabetes Mellitus, Type 2 / drug therapy
  • Female
  • Fertility / drug effects*
  • Glucagon-Like Peptide 1 / adverse effects
  • Glucagon-Like Peptide 1 / analogs & derivatives*
  • Humans
  • Hypoglycemic Agents / adverse effects*
  • Infertility, Male / chemically induced*
  • Liraglutide
  • Male
  • Obesity / complications
  • Obesity / drug therapy
  • Pregnancy
  • Pregnancy Outcome
  • Sperm Count
  • Sperm Injections, Intracytoplasmic
  • Sperm Motility / drug effects
  • Spermatozoa / drug effects

Substances

  • Hypoglycemic Agents
  • Liraglutide
  • Glucagon-Like Peptide 1