Photodynamic therapy effect of zinc monoamino phthalocyanine-folic acid conjugate adsorbed on single walled carbon nanotubes on melanoma cells

Spectrochim Acta A Mol Biomol Spectrosc. 2015 Feb 25:137:1120-5. doi: 10.1016/j.saa.2014.09.033. Epub 2014 Sep 20.

Abstract

This work reports on the photodynamic therapy effect of zinc monoamino phthalocyanine linked to folic acid represented as ZnMAPc-FA, which was further immobilized onto single walled carbon nanotube represented as ZnMAPc-FA-SWCNT on melanoma A375 cell line, the effect of SWCNT-FA (without ZnMAPc) was also examined. All the compounds were non-toxic to the melanoma A375 cell line in the absence of light. Upon irradiation of the melanoma A375 cell line with a 676 nm diode laser at a power density of 98 mW/cm(2) at 5 J/cm(2) about 60% and 63% cell death was observed in the presence of ZnMAPc-FA and ZnMAPc-FA-SWCNT respectively. SWCNT-FA had no significant photodynamic therapy or photothermal effect to the cell, only 23% of cell death was observed after irradiation.

Keywords: Folic acid; Melanoma cells; Photodynamic therapy; Single walled carbon nanotubes.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cell Line, Tumor
  • Folic Acid*
  • Humans
  • Indoles* / chemistry
  • Indoles* / pharmacology
  • Isoindoles
  • Melanoma / drug therapy*
  • Nanotubes, Carbon / chemistry*
  • Photochemotherapy*
  • Radiation-Sensitizing Agents* / chemistry
  • Radiation-Sensitizing Agents* / pharmacology
  • Vitamin B Complex* / chemistry
  • Vitamin B Complex* / pharmacology
  • Zinc* / chemistry
  • Zinc* / pharmacology

Substances

  • Indoles
  • Isoindoles
  • Nanotubes, Carbon
  • Radiation-Sensitizing Agents
  • Vitamin B Complex
  • Folic Acid
  • Zinc
  • phthalocyanine