Microwave-assisted polyol synthesis of carbon nitride dots from folic acid for cell imaging

Int J Nanomedicine. 2014 Oct 31:9:5071-8. doi: 10.2147/IJN.S68575. eCollection 2014.

Abstract

A green, one-step microwave-assisted polyol synthesis was employed to prepare blue luminescent carbon nitride dots (CNDs) using folic acid molecules as both carbon and nitrogen sources. The as-prepared CNDs had an average size of around 4.51 nm and could be well dispersed in water. Under excitation at 360 nm, the CNDs exhibited a strong blue luminescence and the quantum yield was estimated to be 18.9%, which is greater than that of other reported CNDs. Moreover, the CNDs showed low cytotoxicity and could efficiently label C6 glioma cells, demonstrating their potential in cell imaging.

Keywords: carbon nitride dots (CNDs); cell imaging; folic acid; photoluminescence.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cell Line, Tumor
  • Cell Survival / drug effects
  • Fluorescent Dyes / chemistry*
  • Fluorescent Dyes / toxicity
  • Folic Acid / chemistry*
  • Microwaves*
  • Nanotechnology
  • Nitriles / chemical synthesis*
  • Nitriles / chemistry*
  • Optical Imaging
  • Polymers / chemistry*
  • Quantum Dots / chemistry*
  • Quantum Dots / toxicity
  • Rats

Substances

  • Fluorescent Dyes
  • Nitriles
  • Polymers
  • polyol
  • cyanogen
  • Folic Acid