Investigation of the presence of canine adenovirus (CAdV) in owned dogs in Northern Italy

Res Vet Sci. 2014 Dec;97(3):631-6. doi: 10.1016/j.rvsc.2014.10.010. Epub 2014 Oct 29.

Abstract

The use of a modified live canine adenovirus (CAdV) vaccine has greatly reduced the incidence of infectious canine hepatitis (ICH) in dogs. Nevertheless, cases of CAdV type 1 and 2 (CAdV-1 and CAdV-2) infection have been recently reported posing questions about the epidemiological situation of CAdV in dogs. In order to assess the presence of CAdV, samples from 51 dogs presented at a Veterinary Teaching Hospital in Bologna, Italy, for reasons unrelated with CAdV infection, were tested with a polymerase chain reaction (PCR) assay for CAdV. Thirty dogs (58.8%) were PCR positive for CAdV-2 infection and four of them (7.8%) were positive for CAdV-1. Sequence analysis performed on the obtained PCR products suggests that a genetically stable CAdV-1 strain and different CAdV-2 strains circulate in the canine population examined and that coinfections are relatively frequent.

Keywords: Canine adenovirus; Coinfection; Dog; Italy; Molecular epidemiology.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenoviridae Infections / epidemiology
  • Adenoviridae Infections / veterinary*
  • Adenovirus Vaccines / administration & dosage
  • Adenoviruses, Canine / genetics
  • Adenoviruses, Canine / isolation & purification*
  • Animals
  • Coinfection / epidemiology
  • Coinfection / veterinary*
  • Coinfection / virology
  • Dog Diseases / epidemiology*
  • Dog Diseases / virology*
  • Dogs
  • Italy / epidemiology
  • Polymerase Chain Reaction / veterinary

Substances

  • Adenovirus Vaccines