Abstract
This work demonstrates a design strategy to optimize antimicrobial peptides with an ideal balance of minimal cytotoxicity, enhanced stability, potent cell penetration and effective antimicrobial activity, which hold great promise for the treatment of intracellular microbial infections and potentially systemic anti-infective therapy.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Sequence
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Animals
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Anti-Bacterial Agents / chemistry
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Anti-Bacterial Agents / pharmacology*
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Anti-Bacterial Agents / toxicity*
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Bacteria / drug effects
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Bone Marrow Cells / cytology
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Cell Survival / drug effects
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Drug Design*
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Mice
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Models, Molecular
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Monocytes / cytology
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Monocytes / drug effects
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Nanostructures*
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Peptides / chemistry
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Peptides / pharmacology*
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Peptides / toxicity*
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Protein Conformation
Substances
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Anti-Bacterial Agents
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Peptides