Ultrasmall particles for Gd-MRI and (68) Ga-PET dual imaging

Contrast Media Mol Imaging. 2015 Jul-Aug;10(4):309-19. doi: 10.1002/cmmi.1633. Epub 2014 Dec 5.

Abstract

Nanoparticles made of a polysiloxane matrix and surrounded by 1,4,7,10-tetraazacyclododecane-1-glutaric anhydride-4,7,10-triacetic acid (DOTAGA)[Gd(3+) ] and 2,2'-(7-(1-carboxy-4-((2,5-dioxopyrrolidin-1-yl)oxy)-4-oxobutyl)-1,4,7-triazonane-1,4-diyl)diacetic acid) NODAGA[(68) Ga(3+) ] have been synthesized for positron emission tomography/magnetic resonance (PET/MRI) dual imaging. Characterizations were carried out in order to determine the nature of the ligands available for radiolabelling and to quantify them. High radiolabelling purity (>95%) after (68) Ga labelling was obtained. The MR and PET images demonstrate the possibility of using the nanoparticles for a combined PET/MR imaging scanner. The images show fast renal elimination of the nanoparticles after intravenous injection.

Keywords: PET/MRI; multimodal imaging; nanoparticles.

MeSH terms

  • Acetates / chemistry
  • Acetates / pharmacology
  • Anhydrides / chemistry
  • Anhydrides / pharmacology
  • Animals
  • Cell Line, Tumor
  • Contrast Media* / chemistry
  • Contrast Media* / pharmacology
  • Gadolinium* / chemistry
  • Gadolinium* / pharmacology
  • Gallium* / chemistry
  • Gallium* / pharmacology
  • Heterocyclic Compounds, 1-Ring / chemistry
  • Heterocyclic Compounds, 1-Ring / pharmacology
  • Humans
  • Magnetic Resonance Imaging / methods*
  • Mice
  • Nanoparticles / chemistry*
  • Positron-Emission Tomography / methods*

Substances

  • 1-(1,3-carboxypropyl)-4,7-carboxymethyl-1,4,7-triazacyclononane
  • Acetates
  • Anhydrides
  • Contrast Media
  • DOTAGA-anhydride
  • Heterocyclic Compounds, 1-Ring
  • Gadolinium
  • Gallium