We report the first slightly tilted Bragg gratings photo-inscription in polymer optical fiber (POF). For this, we make use of trans-4-stilbenemethanol-doped photosensitive step-index poly(methyl methacrylate) (PMMA) POFs. Tilted fiber Bragg gratings (TFBGs) are inscribed in the near-infrared wavelength range using the scanning phase mask technique with a tilted phase mask in the plane perpendicular to the laser beam direction. The transmitted amplitude spectrum evolution of a 3° TFBG is analyzed as a function of the surrounding refractive index. A maximum sensitivity close to 13 nm/RIU (refractive index unit) is obtained in the range 1.42-1.49.