Abstract
Five new sulfide diketopiperazine derivatives, namely, penicibrocazines A-E (1-5), along with a known congener (6), were isolated and identified from the culture extract of Penicillium brocae MA-231, an endophytic fungus obtained from the fresh tissue of the marine mangrove plant Avicennia marina. The structures of these compounds were elucidated by detailed interpretation of NMR and mass spectroscopic data and the structures of compounds 1 and 3 were confirmed by single-crystal X-ray diffraction analysis. All these compounds were examined for cytotoxic and antimicrobial activities. Compounds 2-6 exhibited antimicrobial activity against some of the tested strains with MIC values ranging from 0.25 to 64 μg/mL.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Infective Agents / chemistry
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Anti-Infective Agents / isolation & purification
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Anti-Infective Agents / pharmacology
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Avicennia / microbiology
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Diketopiperazines / chemistry
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Diketopiperazines / isolation & purification*
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Diketopiperazines / pharmacology
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Heterocyclic Compounds, 4 or More Rings / chemistry
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Heterocyclic Compounds, 4 or More Rings / isolation & purification*
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Heterocyclic Compounds, 4 or More Rings / pharmacology
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Magnetic Resonance Spectroscopy
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Mass Spectrometry
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Microbial Sensitivity Tests
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Micrococcus luteus / drug effects
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Molecular Structure
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Penicillium / chemistry*
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Staphylococcus aureus / drug effects
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Sulfides / chemistry
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Sulfides / isolation & purification
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Sulfides / pharmacology
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X-Ray Diffraction
Substances
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Anti-Infective Agents
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Diketopiperazines
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Heterocyclic Compounds, 4 or More Rings
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Sulfides