Innate lymphoid cells: new insights into function and development

Victor S Cortez; Michelle L Robinette; Marco Colonna

doi:10.1016/j.coi.2015.01.004

Innate lymphoid cells: new insights into function and development

Curr Opin Immunol. 2015 Feb:32:71-7. doi: 10.1016/j.coi.2015.01.004. Epub 2015 Jan 20.

Authors

Victor S Cortez¹, Michelle L Robinette¹, Marco Colonna²

Affiliations

¹ Department of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO 63018, United States.
² Department of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO 63018, United States. Electronic address: mcolonna@pathology.wustl.edu.

Abstract

Here, we illustrate the complexity of ILC subsets and discuss novel functions, focusing on emerging mechanisms of crosstalk with other immune cells and the microbiota. Furthermore, we highlight recent insights into the development of ILCs, including the common pathways they share as well as points of divergence between ILC groups and subsets.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Cell Differentiation*
Humans
Immunity, Innate*
Lymphocyte Subsets / cytology*
Lymphocyte Subsets / physiology*
Lymphoid Progenitor Cells / cytology
Phenotype

Abstract

Publication types

MeSH terms

Grants and funding