Enoyl-coenzyme A hydratase in cancer

Jun Zhang; M M Ibrahim; Mingzhong Sun; Jianwu Tang

doi:10.1016/j.cca.2015.01.020

Enoyl-coenzyme A hydratase in cancer

Clin Chim Acta. 2015 Aug 25:448:13-7. doi: 10.1016/j.cca.2015.01.020. Epub 2015 Jan 27.

Authors

Jun Zhang¹, M M Ibrahim¹, Mingzhong Sun², Jianwu Tang³

Affiliations

¹ Department of Pathology, Dalian Medical University, Dalian 116044, China.
² Department of Biotechnology, Dalian Medical University, Dalian 116044, China.
³ Key Laboratory of Tumor Metastasis of Liaoning Province University, Dalian 116044, China. Electronic address: jwtang_53@sina.cn.

PMID: 25636653
DOI: 10.1016/j.cca.2015.01.020

Abstract

Enoyl-CoA hydratase (Ech) catalyzes the second step in the physiologically important beta-oxidation pathway of fatty acid metabolism. The enzyme was reported to be associated with the progression, metastasis and drug resistance of cancers. It might function as a tumor promoter or a tumor suppressor for certain cancers depending on the particular type or stage of tumor cells/tissues. In this review, Ech's association with malignant tumors as well as its potential mechanisms is discussed and summarized. The enzyme might be useful in the diagnosis, treatment and prognosis determination of certain tumors.

Keywords: Beta-oxidation; Cancer; Enoyl-CoA hydratase (Ech); Fatty acid degradation.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Enoyl-CoA Hydratase / metabolism*
Humans
Neoplasms / diagnosis
Neoplasms / enzymology*
Neoplasms / metabolism

Substances

Enoyl-CoA Hydratase