Abstract
Targeting of vascular intervention by systemically delivered supramolecular nanofibers after balloon angioplasty is described. Tracking of self-assembling peptide amphiphiles using fluorescence shows selective binding to the site of vascular intervention. Cylindrical nanostructures are observed to target the site of arterial injury, while spherical nanostructures with an equivalent diameter display no binding.
Keywords:
peptides; self-assembly; supramolecular chemistry; vascular targeting.
© 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Animals
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Carotid Artery Injuries / drug therapy*
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Carotid Artery Injuries / pathology
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Macromolecular Substances
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Male
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Nanoparticles / administration & dosage*
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Nanoparticles / chemistry*
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Particle Size
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Peptides / administration & dosage*
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Peptides / chemistry*
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Rats
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Rats, Sprague-Dawley
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Surface-Active Agents / administration & dosage*
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Surface-Active Agents / chemistry
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Treatment Outcome
Substances
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Macromolecular Substances
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Peptides
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Surface-Active Agents