Long noncoding RNAs and microRNAs in cardiovascular pathophysiology

Thomas Thum; Gianluigi Condorelli

doi:10.1161/CIRCRESAHA.116.303549

Long noncoding RNAs and microRNAs in cardiovascular pathophysiology

Circ Res. 2015 Feb 13;116(4):751-62. doi: 10.1161/CIRCRESAHA.116.303549.

Authors

Thomas Thum¹, Gianluigi Condorelli²

Affiliations

¹ From the Institute of Molecular and Translational Therapeutic Strategies (IMTTS), Integrated Research and Treatment Center Transplantation, and REBIRTH Excellence Cluster, Hannover Medical School, Hannover, Germany (T.T.); National Heart and Lung Institute, Imperial College London, London, United Kingdom (T.T.); Humanitas Clinical and Research Center, Rozzano, Milan, Italy (G.C.); Institute of Genetics and Biomedical Research, National Research Country of Italy, Milan, Italy (G.C.); University of Milan, Milan, Italy (G.C.); and Department of Cardiovascular Sciences, University of Leicester, Leicester, United Kingdom (G.C.). thum.thomas@mh-hannover.de gianluigi.condorelli@humanitasresearch.it.
² From the Institute of Molecular and Translational Therapeutic Strategies (IMTTS), Integrated Research and Treatment Center Transplantation, and REBIRTH Excellence Cluster, Hannover Medical School, Hannover, Germany (T.T.); National Heart and Lung Institute, Imperial College London, London, United Kingdom (T.T.); Humanitas Clinical and Research Center, Rozzano, Milan, Italy (G.C.); Institute of Genetics and Biomedical Research, National Research Country of Italy, Milan, Italy (G.C.); University of Milan, Milan, Italy (G.C.); and Department of Cardiovascular Sciences, University of Leicester, Leicester, United Kingdom (G.C.).

PMID: 25677521
DOI: 10.1161/CIRCRESAHA.116.303549

Abstract

RNAs not encoding proteins have gained prominence over the last couple of decades as fundamental regulators of cellular function. Not surprisingly, their dysregulation is increasingly being linked to pathology. Here, we review recent reports investigating the pathophysiological relevance of this species of RNA for the cardiovascular system, concentrating mainly on recent findings on long noncoding RNAs and microRNAs in cardiac hypertrophy and failure.

Keywords: cardiac hypertrophy; cardiac remodelling; heart failure; lncRNAs; microRNAs; myocardial infarction.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Cardiovascular Diseases / genetics
Cardiovascular Diseases / metabolism*
Cardiovascular Diseases / physiopathology
Cardiovascular System / metabolism*
Cardiovascular System / physiopathology
Gene Expression Regulation
Genetic Predisposition to Disease
Humans
MicroRNAs / metabolism*
Phenotype
RNA, Long Noncoding / metabolism*
Signal Transduction

Substances

MicroRNAs
RNA, Long Noncoding