Abstract
In this study, photosensitizer conjugated iron oxide nanoparticles were strategically designed and prepared for simultaneous PDT and dual-mode fluorescence/MR imaging. The MRI contrast agent Fe3O4 was modified by APTES to functionalize the surface and further to link with heparin-pheophorbide-A conjugates.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Cell Death / drug effects
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Cell Survival / drug effects
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Chlorophyll / analogs & derivatives*
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Chlorophyll / chemistry
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Chlorophyll / pharmacology
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Contrast Media / chemistry
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Ferric Compounds / chemistry*
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Ferric Compounds / pharmacology
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Fluorescence
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Heparin / chemistry*
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Heparin / pharmacology
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Humans
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KB Cells
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Magnetic Resonance Imaging*
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Nanoparticles / chemistry*
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Photochemotherapy*
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Photosensitizing Agents / chemistry*
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Photosensitizing Agents / pharmacology
Substances
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Contrast Media
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Ferric Compounds
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Photosensitizing Agents
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Chlorophyll
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ferric oxide
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Heparin
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pheophorbide a