Abstract
A series of 2-anilino-1,6-dihydro-6-oxo-5-pyrimidinecarboxylic acids with various substituents was synthesized and evaluated in the rat passive cutaneous anaphylaxis test for antiallergic activity. High activity by intraperitoneal and oral administrations was observed for the 3-trifluoromethyl and 2-alkoxyanilino derivatives (64, 79, 81, 82 and 85). Structure-activity relationships are discussed.
MeSH terms
-
Aniline Compounds / chemical synthesis*
-
Aniline Compounds / pharmacology
-
Aniline Compounds / toxicity
-
Animals
-
Chemical Phenomena
-
Chemistry
-
Histamine H1 Antagonists / chemical synthesis*
-
Histamine H1 Antagonists / pharmacology
-
Histamine H1 Antagonists / toxicity
-
Hypersensitivity / drug therapy*
-
Male
-
Mice
-
Mice, Inbred Strains
-
Passive Cutaneous Anaphylaxis / drug effects
-
Pyrimidines / chemical synthesis*
-
Pyrimidines / pharmacology
-
Pyrimidines / toxicity
-
Rats
-
Rats, Inbred Strains
Substances
-
Aniline Compounds
-
Histamine H1 Antagonists
-
Pyrimidines