Four new cytotoxic xanthones from Garcinia nujiangensis

Fitoterapia. 2015 Apr:102:109-14. doi: 10.1016/j.fitote.2015.02.011. Epub 2015 Feb 27.

Abstract

Bioassay-guided fractionation of the acetone extract of the twigs of Garcinia nujiangensis resulted in the isolation of four new prenylated xanthones, nujiangexanthones C-F (1-4), and ten known related analogues. The structures of compounds 1-4 were elucidated by interpretation of their spectroscopic data. The compounds isolated were evaluated for their cytotoxic effects against three cancer cell lines, the test substances demonstrated selectivity toward the cancer cells.

Keywords: Cudratricusxanthone E (Pubchem CID: 49799569); Cytotoxic; Etoposide I (Pubchem CID: 36462); Garcihombronone B (Pubchem CID: 44559190); Garcinia nujiangensis; Guttiferone F (Pubchem CID: 5352099); Jacareubin (Pubchem CID: 5281644); Nujiangefolin A (Pubchem CID: 66553664); Nujiangefolin B (Pubchem CID: 66553665); Nujiangexanthone A (Pubchem CID: 66553581); Nujiangexanthone B (Pubchem CID: 66553663); Stachyline C (Pubchem CID: 50993978); Xanthone.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents, Phytogenic / chemistry*
  • Antineoplastic Agents, Phytogenic / isolation & purification
  • Cell Line, Tumor
  • Garcinia / chemistry*
  • Humans
  • Molecular Structure
  • Xanthones / chemistry*
  • Xanthones / isolation & purification

Substances

  • Antineoplastic Agents, Phytogenic
  • Xanthones