Generation of electrospun nanofibers with controllable degrees of crimping through a simple, plasticizer-based treatment

Adv Mater. 2015 Apr 24;27(16):2583-8. doi: 10.1002/adma.201500329. Epub 2015 Mar 10.

Abstract

Electrospun nanofibers with controllable degrees of crimping are fabricated by simply exposing the samples to a plasticizer at preset shrinkage ratios. Compared with their straight counterparts, the crimped nanofibers are able to mechanically mimic native tendon tissue and better protect tendon fibroblasts under uniaxial strains.

Keywords: crimping; electrospun nanofibers; plasticizer; scaffold; tendon tissue engineering.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Biomimetic Materials* / chemical synthesis
  • Biomimetic Materials* / chemistry
  • Calorimetry, Differential Scanning
  • Cell Survival
  • Dimethylformamide / chemistry
  • Elastic Modulus
  • Ethanol / chemistry
  • Fibroblasts / cytology
  • Fibroblasts / physiology
  • Lactic Acid / chemistry
  • Materials Testing
  • Microscopy, Electron, Scanning
  • Nanofibers / chemistry*
  • Plasticizers / chemistry*
  • Polyesters / chemistry
  • Polyglycolic Acid / chemistry
  • Polylactic Acid-Polyglycolic Acid Copolymer
  • Polymers / chemistry
  • Polyvinyls / chemistry
  • Spectrum Analysis, Raman
  • Tendons / cytology
  • Tendons / physiology
  • Tissue Scaffolds*

Substances

  • Plasticizers
  • Polyesters
  • Polymers
  • Polyvinyls
  • Polylactic Acid-Polyglycolic Acid Copolymer
  • polyvinylidene fluoride
  • polycaprolactone
  • Polyglycolic Acid
  • Lactic Acid
  • Ethanol
  • poly(lactide)
  • Dimethylformamide