Targeting dengue virus NS4B protein for drug discovery

Antiviral Res. 2015 Jun:118:39-45. doi: 10.1016/j.antiviral.2015.03.007. Epub 2015 Mar 19.

Abstract

The flavivirus nonstructural 4B protein (NS4B) has recently emerged as a valid antiviral target for drug discovery. Here we review (i) the current understanding of the structure and function of DENV NS4B, (ii) the approaches that have been taken to identify NS4B inhibitors, and (iii) the known inhibitors of flavivirus NS4B protein. This article forms part of a symposium in Antiviral Research on flavivirus drug discovery.

Keywords: Antivirals; Dengue; Flavivirus; NS4B; Nonstructural protein 4B.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Antiviral Agents / isolation & purification
  • Antiviral Agents / pharmacology*
  • Dengue Virus / drug effects*
  • Dengue Virus / physiology
  • Drug Discovery / methods
  • Drug Discovery / trends
  • Enzyme Inhibitors / isolation & purification
  • Enzyme Inhibitors / pharmacology*
  • Humans
  • Viral Nonstructural Proteins / antagonists & inhibitors*
  • Viral Nonstructural Proteins / chemistry
  • Viral Nonstructural Proteins / metabolism
  • Virus Replication / drug effects*

Substances

  • Antiviral Agents
  • Enzyme Inhibitors
  • NS4B protein, flavivirus
  • Viral Nonstructural Proteins