Actin and its regulatory proteins play a key role in several essential cellular processes such as cell movement, intracellular trafficking and cytokinesis in most eukaryotes. While these proteins are highly conserved in higher eukaryotes, a number of unicellular eukaryotic organisms contain divergent forms of these proteins which have highly unusual biochemical and structural properties. Here, we review the biochemical and structural properties of these unconventional actins and their core binding proteins which are present in commonly occurring human protozoan parasites.
Keywords: Actin-regulatory proteins; Parasite invasion; Protozoan parasites; Unconventional actins.
Copyright © 2015 Australian Society for Parasitology Inc. Published by Elsevier Ltd. All rights reserved.