Poly(phosphoester)s: A New Platform for Degradable Polymers

Angew Chem Int Ed Engl. 2015 May 18;54(21):6098-108. doi: 10.1002/anie.201500147. Epub 2015 May 7.

Abstract

Poly(phosphoester)s (PPEs) play an important role in nature. They structure and determine life in the form of deoxy- and ribonucleic acid (DNA and RNA), and, as pyrophosphates, they store up chemical energy in organisms. Polymer chemistry, however, is dominated by the nondegradable polyolefins and degradable poly(carboxylic ester)s (PCEs) that are produced on a large scale today. Recent studies have illustrated the potential of PPEs for future applications beyond flame retardancy, and provided a coherent vision to implement this classic biopolymer in modern applications that demand biocompatibility and degradability as well as the possibility to adjust the properties to individual needs.

Keywords: degradable polymers; phosphorus; poly(phosphoester)s; polyesters; polymer synthesis.