Macrophage Cell Membrane Camouflaged Mesoporous Silica Nanocapsules for In Vivo Cancer Therapy

Adv Healthc Mater. 2015 Aug 5;4(11):1645-52. doi: 10.1002/adhm.201500129. Epub 2015 May 8.

Abstract

Engineering natural macrophage cell membrane-camouflaged mesoporous silica nanocapsules can reduce the arrested percentage of immune cells and tissues, effectively prolong the survival time of nanoparticles in blood circulation system, and improve the accumulation in tumor.

Keywords: blood circulation; cell membrane; chemotherapy; drug delivery; mesoporous silica nanocapsules.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antibiotics, Antineoplastic / administration & dosage
  • Antibiotics, Antineoplastic / chemistry
  • Antibiotics, Antineoplastic / toxicity
  • Cell Line, Tumor
  • Cell Survival / drug effects
  • Doxorubicin / administration & dosage
  • Doxorubicin / chemistry
  • Doxorubicin / toxicity
  • Drug Carriers / chemistry
  • Macrophages / cytology
  • Macrophages / drug effects
  • Macrophages / metabolism
  • Male
  • Mice
  • Mice, Inbred BALB C
  • Mice, Nude
  • Nanocapsules / chemistry*
  • Neoplasms / drug therapy
  • Phagocytosis / drug effects
  • Porosity
  • Silicon Dioxide / chemistry*
  • Tissue Distribution
  • Transplantation, Homologous

Substances

  • Antibiotics, Antineoplastic
  • Drug Carriers
  • Nanocapsules
  • Silicon Dioxide
  • Doxorubicin