Emerging concepts in the molecular basis of pulmonary arterial hypertension: part I: metabolic plasticity and mitochondrial dynamics in the pulmonary circulation and right ventricle in pulmonary arterial hypertension

Circulation. 2015 May 12;131(19):1691-702. doi: 10.1161/CIRCULATIONAHA.114.006979.
No abstract available

Keywords: glucose oxidation; glycolysis; heart failure; hypertension, pulmonary; mitochondria; mitochondrial dynamics; positron emission tomography.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adaptation, Physiological
  • Adenosine Triphosphate / biosynthesis
  • Animals
  • Disease Models, Animal
  • Energy Metabolism
  • Fatty Acids / metabolism
  • Glycolysis
  • Heart Failure / etiology
  • Heart Failure / physiopathology
  • Heart Ventricles / metabolism
  • Humans
  • Hypertension, Pulmonary / metabolism*
  • Hypertension, Pulmonary / physiopathology
  • Hypoxia-Inducible Factor 1, alpha Subunit / physiology
  • Mitochondria, Heart / physiology*
  • Mitochondrial Dynamics
  • Oxygen / blood
  • Pulmonary Circulation*
  • Pyruvate Dehydrogenase Complex / metabolism
  • Rats
  • Superoxide Dismutase / metabolism

Substances

  • Fatty Acids
  • HIF1A protein, human
  • Hypoxia-Inducible Factor 1, alpha Subunit
  • Pyruvate Dehydrogenase Complex
  • Adenosine Triphosphate
  • Superoxide Dismutase
  • superoxide dismutase 2
  • Oxygen