Abstract
The last decade has witnessed an explosion of studies evaluating the impact of the human microbiota on a variety of disease states. The microbiota can impact diseases in multiple ways, including through abnormalities in the diversity and contents of the microbiota, as well as by acting as targets of immunologic dysregulation. Herein, evidence that the microbiota in spondyloarthritis is both altered and abnormally targeted by the immune system will be presented.
Keywords:
Inflammatory bowel disease; Microbiome; Microbiota; Spondyloarthritis.
Copyright © 2015 Elsevier Inc. All rights reserved.
Publication types
-
Research Support, N.I.H., Extramural
-
Research Support, Non-U.S. Gov't
-
Review
MeSH terms
-
Animals
-
Arthritis, Juvenile / immunology
-
Arthritis, Juvenile / microbiology
-
Arthritis, Psoriatic / immunology
-
Arthritis, Psoriatic / microbiology
-
Arthritis, Reactive / immunology
-
Arthritis, Reactive / microbiology
-
Gastrointestinal Microbiome / immunology*
-
Humans
-
Immune System / immunology
-
Inflammation
-
Inflammatory Bowel Diseases / immunology*
-
Inflammatory Bowel Diseases / microbiology
-
Intestines / immunology*
-
Intestines / microbiology
-
Mice
-
Spondylarthropathies / immunology*
-
Spondylarthropathies / microbiology
-
Spondylitis, Ankylosing / immunology
-
Spondylitis, Ankylosing / microbiology