Abstract
The Science in 2010 (Sugahara et al., 2010). The key experiments being replicated include Figure 2 and Supplemental Figure 9A. In Figure 2, Sugahara and colleagues presented data on the tumor penetrance of doxorubicin (DOX) when co-administered with the peptide iRGD, as well as the effect of co-treatment of DOX and iRGD on tumor weight and cell death. In Supplemental Figure 9A, they tracked body weight of mice treated with DOX and iRGD to provide evidence that iRGD does not increase known DOX toxicity. The Reproducibility Project: Cancer Biology is a collaboration between the eLife.
Keywords:
Reproducibility Project: Cancer Biology; human; human biology; medicine; methodology; tumor penetrating peptide.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antibiotics, Antineoplastic / metabolism
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Antibiotics, Antineoplastic / pharmacokinetics
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Antibiotics, Antineoplastic / pharmacology*
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Biological Transport
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Cell-Penetrating Peptides / metabolism
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Cell-Penetrating Peptides / pharmacokinetics*
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Doxorubicin / metabolism
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Doxorubicin / pharmacokinetics
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Doxorubicin / pharmacology*
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Drug Carriers / metabolism
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Drug Carriers / pharmacokinetics*
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Male
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Mice
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Mice, Inbred BALB C
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Mice, Nude
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Oligopeptides / metabolism
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Oligopeptides / pharmacokinetics*
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Permeability
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Prostatic Neoplasms / drug therapy*
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Prostatic Neoplasms / metabolism
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Prostatic Neoplasms / pathology
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Treatment Outcome
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Tumor Burden / drug effects
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Xenograft Model Antitumor Assays
Substances
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Antibiotics, Antineoplastic
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Cell-Penetrating Peptides
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Drug Carriers
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N-end cysteine peptide tumor-homing peptide
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Oligopeptides
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Doxorubicin