Alterations in acute myeloid leukaemia bone marrow stromal cell exosome content coincide with gains in tyrosine kinase inhibitor resistance

Br J Haematol. 2016 Mar;172(6):983-6. doi: 10.1111/bjh.13551. Epub 2015 Jun 11.

Shelton Viola¹, Elie Traer², Jianya Huan¹, Noah I Hornick¹, Jeffrey W Tyner^{2

3}, Anupriya Agarwal⁴, Marc Loriaux^{2

3

5}, Brian Johnstone⁶, Peter Kurre^{7

8

9}

¹ Pape Family Pediatric Research Institute, Oregon Health & Science University, Portland, OR, USA.
² Knight Cancer Institute, Oregon Health & Science University, Portland, OR, USA.
³ Cell, Developmental & Cancer Biology, Oregon Health & Science University, Portland, OR, USA.
⁴ Department of Molecular and Cellular Genetics, Oregon Health & Science University, Portland, OR, USA.
⁵ Department of Pathology, Oregon Health & Science University, Portland, OR, USA.
⁶ Orthopaedics and Rehabilitation, Oregon Health & Science University, Portland, OR, USA.
⁷ Pape Family Pediatric Research Institute, Oregon Health & Science University, Portland, OR, USA. kurrepe@ohsu.edu.
⁸ Knight Cancer Institute, Oregon Health & Science University, Portland, OR, USA. kurrepe@ohsu.edu.
⁹ Cell, Developmental & Cancer Biology, Oregon Health & Science University, Portland, OR, USA. kurrepe@ohsu.edu.

No abstract available

Keywords: acute myeloid leukaemia; chemo-resistance; exosomes; microRNA; stroma.

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