Electrical Stimulation of Human Mesenchymal Stem Cells on Conductive Nanofibers Enhances their Differentiation toward Osteogenic Outcomes

John G Hardy; Maria K Villancio-Wolter; Rushi C Sukhavasi; David J Mouser; David Aguilar Jr; Sydney A Geissler; David L Kaplan; Christine E Schmidt

doi:10.1002/marc.201500233

Electrical Stimulation of Human Mesenchymal Stem Cells on Conductive Nanofibers Enhances their Differentiation toward Osteogenic Outcomes

Macromol Rapid Commun. 2015 Nov;36(21):1884-1890. doi: 10.1002/marc.201500233. Epub 2015 Jul 6.

Authors

Affiliations

¹ J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, FL, 32611, USA.
² Department of Biomedical Engineering, The University of Texas at Austin, Austin, TX, 78712, USA.
³ Department of Biomedical Engineering, Tufts University, Medford, MA, 02155, USA.

PMID: 26147073
DOI: 10.1002/marc.201500233

Abstract

Tissue scaffolds allowing the behavior of the cells that reside within them to be controlled are of particular interest for tissue engineering. Herein, the preparation of conductive fiber-based bone tissue scaffolds (nonwoven mats of electrospun polycaprolactone with an interpenetrating network of polypyrrole and polystyrenesulfonate) is described that enable the electrical stimulation of human mesenchymal stem cells to enhance their differentiation toward osteogenic outcomes.

Keywords: bone; conducting polymers; electrical stimulation; stem cells; tissue scaffolds.