4S Peak Filling - baseline estimation by iterative mean suppression

MethodsX. 2015 Feb 21:2:135-40. doi: 10.1016/j.mex.2015.02.009. eCollection 2015.

Abstract

A novel baseline estimation procedure building on previously published works is presented. •The core of the estimation is an iterative spectrum suppression consisting of a moving window minimum replacement (adapted from Friedrichs [1]).•Four, easily understandable, parameters control placement of the baseline relative to the noise band around the signal (adapted from Eilers [2]) and the flexibility in different situations.•The method is especially suited for non-linear baselines with local variations and for resolving peak clusters in qualitative analyses.

Keywords: Baseline estimation; Baseline estimation by iterative mean suppression; Interpolation; Moving window; Noise; Smoothing; Subsampling.