Folate-polydiacetylene-liposome for tumor targeted drug delivery and fluorescent tracing

Lielie Li; Xueqin An; Xiaojuan Yan

doi:10.1016/j.colsurfb.2015.07.008

Folate-polydiacetylene-liposome for tumor targeted drug delivery and fluorescent tracing

Colloids Surf B Biointerfaces. 2015 Oct 1:134:235-9. doi: 10.1016/j.colsurfb.2015.07.008. Epub 2015 Jul 13.

Authors

Lielie Li¹, Xueqin An², Xiaojuan Yan¹

Affiliations

¹ Department of Chemistry, Institute of Chemistry and Molecular Engineering, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, PR China.
² Department of Chemistry, Institute of Chemistry and Molecular Engineering, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, PR China. Electronic address: anxueqin@ecust.edu.cn.

PMID: 26208294
DOI: 10.1016/j.colsurfb.2015.07.008

Abstract

A novel folate-polydiacetylene-liposome (FP-PL) with both targeted drug delivery and fluorescence tracing was prepared by thin film rehydration method. The simulated drug delivery was performed in Bcap-37 breast cancer cells and Hs578Bst normal cells in vitro. The internalization and distribution of FP-PLs in the cells were presented by fluorescence cell imaging. The results show that the FP-PLs possess low cytotoxicity, good biocompatibility and better targeting efficiency in comparison to polydiacetylene-liposomes (P-PLs).

Keywords: Fluorescent imaging; Folic acid; Liposome; Polydiacetylene; Targeted drug delivery.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Cell Line, Tumor
Drug Delivery Systems*
Folic Acid / chemistry*
Humans
Liposomes*
Microscopy, Fluorescence / methods*
Polyacetylene Polymer
Polymers / chemistry*
Polyynes / chemistry*

Substances

Liposomes
Polyacetylene Polymer
Polymers
Polyynes
polydiacetylene
Folic Acid