A thiol-thiosulfonate reaction providing a novel strategy for turn-on thiol sensing

Chem Commun (Camb). 2015 Oct 14;51(80):14913-6. doi: 10.1039/c5cc05390k.

Abstract

The first thiol-specific turn-on probe, BODIPY-TS, utilizing a thiosulfonate scaffold as the thiol recognition unit was reported. BODIPY-TS displays low toxicity, and features high sensitivity, fast response and quantitative reaction towards thiols. The structural novelty of BODIPY-TS would guide the development of novel thiol probes.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Sulfhydryl Compounds / analysis
  • Sulfhydryl Compounds / chemistry*
  • Thiosulfonic Acids / analysis*

Substances

  • Sulfhydryl Compounds
  • Thiosulfonic Acids