The electrochemical oxidation of p-nitrophenol (p-Np) has been studied on glassy carbon electrode modified with the single-walled carbon nanotubes/silver nanowires hybrids (SWNTs-Ag) by using cyclic and differential pulse voltammetry. p-Np is irreversibly oxidized at +0.88 V (vs. the Ag/AgCl) in PBS solutions of pH 7.4. The modified electrodes display the detection sensitivity of 0.0212 µA/µM with an unusually wide linear response of 5-1700 µM (R2 = 0.998) and the detection limit of 1 µM. The current response of SWNTs-Ag modified electrode to p-Np is better than that of SWNTs or Ag nanowires modified electrode under the same concentration. Combining the adsorption ability of SWNTs and the conductivity of SWNTs and Ag nanowires, the detection performance of SWNTs-Ag modified electrode to p-Np was greatly improved.