Abstract
The article focuses on the clinical and laboratory diagnosis of human granulocytic anaplasmosis (HGA) caused by Anaplasma phagocytophilum infection in one of 28 patients (3.6%; n=1/28 tested samples) with early Lyme borreliosis. The clinical and laboratory results of a 42-year-old patient fulfilled criteria of confirm anaplasmosis and suggest an acute stage of illness. The described case provides strong presumptive evidence that infection in this patient was acquired with a pathogenic strain of A. phagocytophilum through a tick bite. A positive DNA with PCR for A. phagocytophilum infection was sequenced and analyzed phylogenetically. Physicians should consider the possibility of anaplasmosis in patients with early Lyme borreliosis, and A. phagocytophilum should be considered as a differential diagnosis in all patients from an endemic region of potential high risk factors for tick-borne diseases.
Publication types
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Case Reports
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Amoxicillin / therapeutic use
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Anaplasma phagocytophilum / genetics
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Anaplasma phagocytophilum / isolation & purification*
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Anaplasma phagocytophilum / metabolism
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Anti-Bacterial Agents / therapeutic use
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Bacterial Proteins / genetics
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Bacterial Proteins / metabolism
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Ceftriaxone / therapeutic use
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Chaperonins / genetics
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Chaperonins / metabolism
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Coinfection / microbiology
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Diagnosis, Differential
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Ehrlichiosis / diagnosis*
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Ehrlichiosis / drug therapy
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Ehrlichiosis / microbiology
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Humans
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Lyme Disease / microbiology
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Male
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Molecular Sequence Data
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Phylogeny
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Poland
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RNA, Ribosomal, 16S / genetics
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RNA, Ribosomal, 16S / metabolism
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Sequence Analysis, DNA
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Tick-Borne Diseases / diagnosis*
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Tick-Borne Diseases / drug therapy
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Tick-Borne Diseases / microbiology
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Treatment Outcome
Substances
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Anti-Bacterial Agents
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Bacterial Proteins
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GroESL protein, Bacteria
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RNA, Ribosomal, 16S
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Ceftriaxone
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Amoxicillin
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Chaperonins