IP-10/CXCL10 attracts regulatory T cells: Implication for pancreatic cancer

Serena Lunardi; Su Yin Lim; Ruth J Muschel; Thomas B Brunner

doi:10.1080/2162402X.2015.1027473

IP-10/CXCL10 attracts regulatory T cells: Implication for pancreatic cancer

Oncoimmunology. 2015 Apr 2;4(9):e1027473. doi: 10.1080/2162402X.2015.1027473. eCollection 2015 Sep.

Authors

Serena Lunardi¹, Su Yin Lim¹, Ruth J Muschel², Thomas B Brunner³

Affiliations

¹ Gray Institute for Radiation Oncology and Biology; Department of Oncology; University of Oxford ; Oxford, UK.
² Gray Institute for Radiation Oncology and Biology; Department of Oncology; University of Oxford ; Oxford, UK ; These authors contributed equally to this work.
³ Gray Institute for Radiation Oncology and Biology; Department of Oncology; University of Oxford ; Oxford, UK ; Department of Radiation Oncology; University Hospitals Freiburg ; Freiburg, Germany ; These authors contributed equally to this work.

Abstract

Pancreatic stellate cells (PSCs) are key components of pancreatic ductal adenocarcinoma (PDAC). We recently demonstrated that IP-10/CXCL10 is highly expressed by PSCs in the presence of pancreatic cancer cells (PCCs) and its expression correlates with infiltration by regulatory T cells (Tregs) and poor survival. Thus, stromal cells in pancreatic cancer can promote immunosuppression and tumor progression, through the expression of IP-10.

Keywords: CXCL10; IP-10; pancreatic cancer; pancreatic stellate cells; regulatory T cells.

Publication types

Research Support, Non-U.S. Gov't

Abstract

Publication types

Grants and funding