Recent advances in dengue pathogenesis and clinical management

Cameron P Simmons; Kirsty McPherson; Nguyen Van Vinh Chau; D T Hoai Tam; Paul Young; Jason Mackenzie; Bridget Wills

doi:10.1016/j.vaccine.2015.09.103

Recent advances in dengue pathogenesis and clinical management

Vaccine. 2015 Dec 10;33(50):7061-8. doi: 10.1016/j.vaccine.2015.09.103. Epub 2015 Oct 14.

Authors

Cameron P Simmons¹, Kirsty McPherson², Nguyen Van Vinh Chau³, D T Hoai Tam⁴, Paul Young⁵, Jason Mackenzie², Bridget Wills⁶

Affiliations

¹ Oxford University Clinical Research Unit, Hospital for Tropical Diseases, 764 Vo Van Kiet street, District 5, Ho Chi Minh City, Viet Nam; Centre for Tropical Medicine, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom; Department of Microbiology and Immunology, University of Melbourne, Parkville, Victoria 3010, Australia. Electronic address: csimmons@oucru.org.
² Department of Microbiology and Immunology, University of Melbourne, Parkville, Victoria 3010, Australia.
³ Hospital for Tropical Diseases, 764 Vo Van Kiet, District 5, Ho Chi Minh City, Viet Nam.
⁴ University of Medicine and Pharmacy, 217 Hong Bang, District 5, Ho Chi Minh City, Viet Nam.
⁵ School of Chemistry and Molecular Biosciences, University of Queensland, Australia.
⁶ Oxford University Clinical Research Unit, Hospital for Tropical Diseases, 764 Vo Van Kiet street, District 5, Ho Chi Minh City, Viet Nam; Centre for Tropical Medicine, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.

PMID: 26458808
DOI: 10.1016/j.vaccine.2015.09.103

Abstract

This review describes and commentates on recent advances in the understanding of dengue pathogenesis and immunity, plus clinical research on vaccines and therapeutics. We expand specifically on the role of the dermis in dengue virus infection, the contribution of cellular and humoral immune responses to pathogenesis and immunity, NS1 and mechanisms of virus immune evasion. Additionally we review a series of therapeutic intervention trials for dengue, as well as recent clinical research aimed at improving clinical diagnosis, risk prediction and disease classification.

Keywords: Clinical research; Dengue; Immunology; Pathogenesis; Vaccine; Virology.

Publication types

Review

MeSH terms

Adaptive Immunity
Dengue / diagnosis
Dengue / epidemiology
Dengue / pathology*
Dengue / therapy*
Diagnostic Tests, Routine
Host-Pathogen Interactions
Humans
Immune Evasion
Immunity, Cellular
Immunity, Humoral
Immunity, Innate
Immunotherapy / methods
Immunotherapy / trends