Abstract
Five new ambuic acid analogues, penicyclones A-E (1-5), were isolated from the extract of the deep-sea-derived fungus Penicillium sp. F23-2. The structures including the absolute configurations were established by interpretation of NMR and MS data, as well as the application of ECD, X-ray crystallography, and a chemical conversion, as well as the TDDFT-ECD calculations. Penicyclones A-E (1-5) exhibited antimicrobial activity against the Gram-positive bacterium Staphylococcus aureus with MIC values ranging from 0.3 to 1.0 μg/mL.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Bacterial Agents / chemistry
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Anti-Bacterial Agents / isolation & purification*
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Anti-Bacterial Agents / pharmacology*
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Crystallography, X-Ray
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Doxorubicin / pharmacology
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Drug Screening Assays, Antitumor
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Gram-Positive Bacteria / drug effects
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HCT116 Cells
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HEK293 Cells
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HeLa Cells
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Humans
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Marine Biology
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Microbial Sensitivity Tests
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Molecular Conformation
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
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Penicillium / chemistry*
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Polyketides / chemistry
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Polyketides / isolation & purification*
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Polyketides / pharmacology*
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Staphylococcus aureus / drug effects
Substances
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Anti-Bacterial Agents
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Polyketides
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Doxorubicin