Abstract
We assessed the prevalence of six biocide resistance genes among 82 methicillin-resistant Staphylococcus aureus (MRSA) and 219 methicillin-susceptible S. aureus (MSSA) isolates from three African countries; the prevalence was very high for sepA (95.3%), mepA (89.4%), and norA (86.4%), intermediate for lmrS (60.8%) and qacAB (40.5%), and low for smr (3.7%). A significant association between biocide resistance genes and antibiotic resistance was observed, and a new cutoff MIC of ≥1 mg/liter for chlorhexidine nonsusceptibility was defined.
Copyright © 2015, American Society for Microbiology. All Rights Reserved.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Angola / epidemiology
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Anti-Infective Agents, Local / pharmacology*
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Atlantic Islands / epidemiology
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Bacterial Proteins / genetics*
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Bacterial Proteins / metabolism
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Cabo Verde / epidemiology
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Chlorhexidine / pharmacology*
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Gene Expression
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Humans
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Methicillin-Resistant Staphylococcus aureus / drug effects*
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Methicillin-Resistant Staphylococcus aureus / genetics
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Methicillin-Resistant Staphylococcus aureus / growth & development
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Microbial Sensitivity Tests
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Multidrug Resistance-Associated Proteins / genetics*
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Multidrug Resistance-Associated Proteins / metabolism
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Prevalence
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Staphylococcal Infections / epidemiology*
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Staphylococcal Infections / microbiology
Substances
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Anti-Infective Agents, Local
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Bacterial Proteins
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Multidrug Resistance-Associated Proteins
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NorA protein, Staphylococcus
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Chlorhexidine