Abstract
A series of β-boswellic acid derivatives were synthesized and evaluated for anticancer activity. One of the lead analog 4f displayed significant anticancer activity against a panel of cancer cells as well as substantially inhibited colony formation in HCT-116 cells. Furthermore, 4f was found to be a potent inducer of apoptosis confirmed by loss of mitochondrial membrane potential, DAPI staining, Western blotting and ROS generation.
Keywords:
Anticancer; Apoptosis; Triterpenoid; β-Boswellic acid.
Copyright © 2015 Elsevier Ltd. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents / chemical synthesis*
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / metabolism
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Antineoplastic Agents / pharmacology*
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Apoptosis / drug effects*
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Cell Proliferation / drug effects
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Dose-Response Relationship, Drug
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Drug Screening Assays, Antitumor
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HCT116 Cells
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Humans
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Molecular Conformation
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Structure-Activity Relationship
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Triterpenes / chemical synthesis
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Triterpenes / chemistry*
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Triterpenes / pharmacology*
Substances
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Antineoplastic Agents
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Triterpenes
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boswellic acid