One-step fabrication of inorganic/organic hybrid microspheres with tunable surface texture for controlled drug release application

Hua Dong; Guannan Tang; Ting Ma; Xiaodong Cao

doi:10.1007/s10856-015-5624-y

One-step fabrication of inorganic/organic hybrid microspheres with tunable surface texture for controlled drug release application

J Mater Sci Mater Med. 2016 Jan;27(1):7. doi: 10.1007/s10856-015-5624-y. Epub 2015 Nov 26.

Authors

Hua Dong^{1

2}, Guannan Tang^{3

4}, Ting Ma^{3

5}, Xiaodong Cao^{6

7

8}

Affiliations

¹ Department of Biomedical Engineering, School of Materials Science and Engineering, South China University of Technology, Guangzhou, 510641, China. donghua@scut.edu.cn.
² Guangdong Province Key Laboratory of Biomedical Engineering, South China University of Technology, Guangzhou, 510006, China. donghua@scut.edu.cn.
³ Department of Biomedical Engineering, School of Materials Science and Engineering, South China University of Technology, Guangzhou, 510641, China.
⁴ Guangdong Province Key Laboratory of Biomedical Engineering, South China University of Technology, Guangzhou, 510006, China.
⁵ National Engineering Research Center for Tissue Restoration and Reconstruction, Guangzhou, 510006, China.
⁶ Department of Biomedical Engineering, School of Materials Science and Engineering, South China University of Technology, Guangzhou, 510641, China. caoxd@scut.edu.cn.
⁷ Guangdong Province Key Laboratory of Biomedical Engineering, South China University of Technology, Guangzhou, 510006, China. caoxd@scut.edu.cn.
⁸ National Engineering Research Center for Tissue Restoration and Reconstruction, Guangzhou, 510006, China. caoxd@scut.edu.cn.

PMID: 26610930
DOI: 10.1007/s10856-015-5624-y

Abstract

In this paper, we report one-step fabrication of poly(lactide-co-glycolic acid)/titanium oxide (PLGA/TiO2) hybrid microspheres with tunable surface texture via droplet-based microfluidics. Surface texture of microspheres can be continuously tuned by changing the mass ratio between titanium tetraisopropoxide (TTIP) and PLGA in the dispersed phase. The fast hydrolysis of TTIP on the droplet surface can generate a thin shell membrane, resulting in a wrinkled surface after extraction of organic solvent. In vitro drug release monitoring of tanshinone IIA-loaded PLGA/TiO2 hybrid microsphere reveals that surface texture can affect the drug release rate to a large extent without sacrificing the drug encapsulation efficiency. Our finding might benefit the sustained drug delivery where variable drug release rate and high drug encapsulation efficiency are both required.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Hydrolysis
Inorganic Chemicals / chemistry*
Microscopy, Electron, Scanning
Microspheres*
Organic Chemicals / chemistry*
Pharmaceutical Preparations / administration & dosage*
Surface Properties

Substances

Inorganic Chemicals
Organic Chemicals
Pharmaceutical Preparations